% Generated by roxygen2: do not edit by hand
% Please edit documentation in R/recurrent.marginal.R
\name{simMultistate}
\alias{simMultistate}
\alias{extendCums}
\title{Simulation of illness-death model}
\usage{
simMultistate(
  n,
  cumhaz,
  cumhaz2,
  death.cumhaz,
  death.cumhaz2,
  rr = NULL,
  rr2 = NULL,
  rd = NULL,
  rd2 = NULL,
  gap.time = FALSE,
  max.recurrent = 100,
  dependence = 0,
  var.z = 0.22,
  cor.mat = NULL,
  cens = NULL,
  ...
)
}
\arguments{
\item{n}{number of id's}

\item{cumhaz}{cumulative hazard of going from state 1 to 2.}

\item{cumhaz2}{cumulative hazard of going from state 2 to 1.}

\item{death.cumhaz}{cumulative hazard of death from state 1.}

\item{death.cumhaz2}{cumulative hazard of death from state 2.}

\item{rr}{relative risk adjustment for cumhaz}

\item{rr2}{relative risk adjustment for cumhaz2}

\item{rd}{relative risk adjustment for death.cumhaz}

\item{rd2}{relative risk adjustment for death.cumhaz2}

\item{gap.time}{if true simulates gap-times with specified cumulative hazard}

\item{max.recurrent}{limits number recurrent events to 100}

\item{dependence}{0:independence; 1:all share same random effect with variance var.z; 2:random effect exp(normal) with correlation structure from cor.mat; 3:additive gamma distributed random effects, z1= (z11+ z12)/2 such that mean is 1 , z2= (z11^cor.mat(1,2)+ z13)/2, z3= (z12^(cor.mat(2,3)+z13^cor.mat(1,3))/2, with z11 z12 z13 are gamma with mean and variance 1 , first random effect is z1 and for N1 second random effect is z2 and for N2 third random effect is for death}

\item{var.z}{variance of random effects}

\item{cor.mat}{correlation matrix for var.z variance of random effects}

\item{cens}{rate of censoring exponential distribution}

\item{...}{Additional arguments to lower level funtions}
}
\description{
Simulation of illness-death model
}
\details{
simMultistate with different death intensities from states 1 and 2 

Must give cumulative hazards on some time-range
}
\examples{
########################################
## getting some rates to mimick 
########################################
data(base1cumhaz)
data(base4cumhaz)
data(drcumhaz)
dr <- drcumhaz
dr2 <- drcumhaz
dr2[,2] <- 1.5*drcumhaz[,2]
base1 <- base1cumhaz
base4 <- base4cumhaz
cens <- rbind(c(0,0),c(2000,0.5),c(5110,3))

iddata <- simMultistate(100,base1,base1,dr,dr2,cens=cens)
dlist(iddata,.~id|id<3,n=0)
 
### estimating rates from simulated data  
c0 <- phreg(Surv(start,stop,status==0)~+1,iddata)
c3 <- phreg(Surv(start,stop,status==3)~+strata(from),iddata)
c1 <- phreg(Surv(start,stop,status==1)~+1,subset(iddata,from==2))
c2 <- phreg(Surv(start,stop,status==2)~+1,subset(iddata,from==1))
###
par(mfrow=c(2,3))
bplot(c0)
lines(cens,col=2) 
bplot(c3,main="rates 1-> 3 , 2->3")
lines(dr,col=1,lwd=2)
lines(dr2,col=2,lwd=2)
###
bplot(c1,main="rate 1->2")
lines(base1,lwd=2)
###
bplot(c2,main="rate 2->1")
lines(base1,lwd=2)
 
}
\author{
Thomas Scheike
}
